What Are the Deadliest Diseases in History?
WHO estimates tuberculosis killed 1.23 million people worldwide in 2024, more than any other single infectious agent; hepatitis B killed about 1.1 million.
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WHO estimates tuberculosis killed 1.23 million people worldwide in 2024, more than any other single infectious agent; hepatitis B killed about 1.1 million.

Alaska had the highest reported TB rate of any state in 2025, 10.4 cases per 100,000 people, in CDC provisional data.

In 2024, 30.1 of every 1,000 US live births were twins, about 1 in 33 babies (3.0%), according to final CDC natality data.
Source: CDC National Center for Health Statistics · Data year 2024 · per year

About 1 in 3 US births, 32.5%, were cesarean deliveries in the 12 months ending June 2026, provisional CDC data show.

About 1 in 9 Americans age 65 and older, an estimated 7.4 million people, live with Alzheimer's dementia in 2026, the Alzheimer's Association reports.

Food poisoning costs the US about $74.7 billion a year in 2023 dollars, across about 47.8 million illnesses, USDA Economic Research Service estimates.

CDC surveillance shows an average of 26.8 US tetanus cases a year from 2009 to 2023, and 18 in 2023, about 1 in 18.6 million people.

In 2017 to March 2020, 11.1% of US children ages 2 to 5 had untreated decay in their baby teeth, and 50.1% of those ages 6 to 9 had ever had tooth decay.

Broken heart syndrome is real: US hospitals admitted about 40,000 patients a year with it from 2016 to 2020, and about 1 in 15 died there (our arithmetic).

Macro image of fresh garlic on rough wooden chopping board Shallow focus. Can eating right prevent cancer? The odds a person will ever be…

Lung cancer causes the most US cancer deaths, a projected 124,990 in 2026; of SEER's common sites, pancreatic has the lowest five year survival, 13.7%.

Even a partial list of body image problems that a child may run up against can be petrifying—anorexia nervosa, bulimia, body dysmorphic disorder, severe…
✱ The Outlier
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